Comparison And Analysis Of Optimization Results Of A New Non-isothermal Simulated Moving Bed

Simulated moving bed(SMB),a continuous counter-current chromatographic separation process,can be reinforced by gradient operations.The performance of a new operation mode of a 8 column system that is featured by an outloop zone with independent temperature adjustment(4+1 zone)was evaluated based on multi-objective optimization results.For more generality,a dimensionless was developed.Moreover,sensitivity analysis of several key parameters were carried out to investigate the multi-dimensional parametric space.Parameters for ketoprofen enantiomers were used as the starting point.Concerned in this study are three major problem as below.The first is two-objective optimization with purity and productivity or solvent consumption as the objectives.Effects of adsorption selectivity(SC)and heat capacity ratio(λ),in the range of 1.3-1.66 and 0.11-0.45,respectively,were systematically examined.The second is a comparison between 4 + 1 zone and conventional 4 zone operations with internal temperature gradients.The results showed that either operation can be superior than the other,depending on the key parameter values.The third is three-objective optimization with purity,productivity and solvent consumption as the objectives.More specifically,the range in which 4 + 1 zone operation is superior than conventional 4 zone operation was investigated.The results further validate those obtained in the two-objective optimization problems.