Atom-economic Synthesis Of Trifluoromethyl Substituted Cyclic N-Sulfonylimines By Electrochemical Tandem Reaction Of Olefins

Trifluoromethyl-substituted organic fluorine compounds have a wide range of applications in pharmaceutical agrochemicals and performance materials.Decoration of small molecules with the trifluoromethyl（CF₃）group has gained attention from industrial and academic communities.Electrochemical methods have become instrumental in organic synthesis,and tandem reactions have also been widely used in electrochemical synthesis as a common strategy in green chemistry.This article developed a strategy for economically synthesizing fluoroalkyl substituted Cyclic N-Sulfonylimines using Langlois’reagent as a bifunctional reagent through electrochemical tandem reactions.The main contents of this paper are as follows:1)First,we introduce the status of trifluoromethylation of olefins with Langlois’reagent as trifluoromethyl radicals.Then we briefly explained the intention of this article.2)We developed the Langlois’reagent as the CF₃ and SO₂ donor to realize the electrochemical trifluoromethylation/SO₂ insertion/tandem cyclization of olefins into trifluoromethyl-substituted Cyclic N-Sulfonylimines3)Based on the previous work,we synthesized difluoromethyl-substituted Cyclic N-Sulfonylimines by electrochemical difluoromethylation/SO₂ insertion/tandem cyclization of olefins with the participation of sodium difluoromethanesulfinate（CHF₂SO₂Na）.