Visible Light-induced Carbon-carbon Bond Formation Through The Free Radical Process

During the development of organic synthesis,visible-light photo-catalysis has received much more attention in the recent years.They have advantages of natural richness,easy to use and sustainability.It is well known that carbon-carbon bond formation is one of the important bond constructions in organic chemistry,and is always a hot topic and plays an important role in modern synthetic chemistry.Because of the development of green chemistry,people are paying more and more attention to photo-catalysis organic synthesis reaction driven by visible light.Visible-light photo-catalysis have advantages of simple method,mild conditions,and environmental friendliness.In this paper,we mainly focus on the study of visible-light-induced formation of carbon-carbon bond,and the related research work was carried out as following:（1）The reaction of N-aryl tetrahydroisoquinoline and carboxylic acid was carried using acetone and H₂O（1:1）as solvent,Na₂HPO₄·12H₂O as a base,and[Acr⁺-Mes]Cl O₄ as a photocatalyst in air atmosphere at room temperature under visible-light（blue LEDs,450-455nm）irradiation conditions,providing the corresponding N-aryl tetrahydroisoquinoline derivatives in good yields.（2）The reaction ofα,β-unsaturated aromatic ketones with sodium trifluoromethylsulfinate was performed in acetone as solvent in the absence of any photocatalyst at room temperature under visible-light irradiation conditions in air,generating the desired phenanthrene-9（10H）-one derivatives in high yields via free-radical addition/cyclization sequence processes.