Application And Research Of Glucose Electrochemical Enzyme-free Sensor Based On MOFs

Metal organic frameworks(MOFs)are a new type of porous crystalline nanomaterials synthesized by connecting various organic ligands through metal nodes.As a new type of nanomaterial,MOFs material is rich in pores,has a high specific surface area and adjustable,attracting the attention of many chemists.MOFs materials are widely used in photoelectromagnetic,energy storage,catalysis,biological In the fields of sensing,gas adsorption,and drug sustained release.However,due to the poor conductivity of MOFs,MOFs have been used as precursors or carbon nanotubes(WMCNT),graphene(ROG),precious metal nanoparticles(NPs)MOFs were modified to increase their conductivity,and a series of MOFs-based derivative materials were prepared.The main research work done in this paper are as follows.By reading the published literature,we proposed a new modification method for preparing new MOFs-based nanomaterials is,and selected three representative MOF materials according to our preparation method for modification.Through liquid-phase synthesis and post-modification synthesis,new metal-organic framework(MOFs)nanocomposites were successfully prepared.The obtained nanocomposite material is used to construct an enzyme-free glucose electrochemical sensor for electrochemical detection of glucose.The obtained nanocomposite materials were tested for related electrochemical properties such as cyclic voltammetry and AC impedance.The sensitivity and detection limit of the sensor were calculated,and the stability and anti-interference ability of the sensor and the detection ability of glucose in the actual blood sample were studied using linear scanning voltammetry.Nano-composite materials were also characterized by structural morphology and other experiments1.Cu-MOF and nickel-doped Ni@Cu-MOF metal-organic framework complexes were synthesized by a simple liquid phase method.2.MOF-808 was synthesized by the solvothermal method,and Ni@MOF-808metal-organic frame composite was obtained by doping the nickel with MOF-808 bythe immersion method.3.UIO-66 was synthesized by solvothermal method,and UIO-66 was doped with nickel by immersion method to obtain Ni@UIO-66 metal-organic frame composite material.Characterization test results showed that the detection results of Powder XRD and FT-IR showed that the structure of Cu-MOF,UIO-66 and MOF-808 did not change before and after modification.SEM and TEM test results show that the micro-morphology of Ni@Cu-MOF,Ni@UIO-66 and Ni@MOF-808 are all two-dimensional flakes.XPS test results show that target elements are detected in Ni@Cu-MOF,Ni@UIO-66 and Ni@MOF-808.EDS Mapping test shows that the elements are evenly distributed in the compound.Electrochemical test results show that Ni@Cu-MOF,Ni@UIO-66 and Ni@MOF-808 all have good detection of glucose in the linear range of 5-2500μM.The detection limit is 1.67μM,which has anti-interference ability to common interfering substances,and has good reproducibility and detection ability of actual samples.