Optimization Of The Laser Processing Parameters In The Synthesis Of PEGDA Nanogels Via Precise Photopolymerization

Precise photopolymerization is a novel form of nanofabrication that offers precise control of the chemical reaction mechanism along with a well-defined spatial resolution,both of which are crucial in the synthesis of nanomaterials for biomedical applications.In this study,poly(ethylene glycol)diacrylate-based nanogels were prepared by using precise photopolymerization under visible light.The effects of random molecular motion and light scattering due to particle size provided a threshold time of 45 s for the synthesis of a detectable size nanoparticle.The threshold time aided in the optimization of laser processing parameters,such as laser power and irradiation time,to an appropriate range for the synthesis of three-dimensional(3D)nanogels.Irradiation for 0.5 s saw a threshold laser power of 40 m W for the synthesis of nanogels.However,the combination of low laser power for a long irradiation time provided nanoparticles with the best degree of polymerization and particle size.With particles as small as 425 nm having a double bond percentage of 19.79 %,the optimal laser processing parameter proved to be irradiation at 10 m W of laser power for 60 s.Hence,such nanogels offer potential applications as drug carriers in biomedicine.