Preparation Of Starch-based Plant Capsules

The hollow capsule used for wrapping the drug particles is a drug auxiliary material,and the hollow capsule does not have curative effect by itself,but enters the digestive system of the human body along with the contained drug and is finally absorbed by the human body.At present,the main raw material of hollow capsules is gelatin.The production process of gelatin is relatively complex,which is mostly obtained by the partial degradation of collagen in animal skin,bone and other tissues.Some gelatin is also derived from industrial leather wastes.The hollow capsule prepared by gelatin is easy to retain animal protein,which will interact with the content drug.At the same time,gelatin capsule is easy to breed microorganisms,is fragile,and is easy to adhere under the condition of high environmental humidity.At the same time,Islam,Judaism and other taboos against animals.As a result,valuable gelatin capsules are rejected,and people have to study new materials to prepare non-gelatin capsules.Starch is considered as the most potential raw material to replace the traditional gelatin capsules and one of the six major nutrients in human body.Due to its advantages of wide source,high utilization rate and low price,starch is increasingly accepted and recognized by people.This paper is divided into two parts: preparation and characterization of starch composite membrane and preparation and properties of hydroxypropyl starch hollow capsules.In the preparation and characterization of starch composite membrane,hydroxypropyl starch was determined by multi-angle analysis of enzymatic hydrolysis time,selection and dosage of gelling agent,type and amount of plasticizer,microscopic observation,solubility and contact angle.The preferred formulation of the composite film,the tensile strength of the hydroxypropyl starch composite film is 4.60 MPa,and the elongation at break is 31.60%;the ratio of hydroxypropyl starch to corn starch,the amount of glycerin,the amount of HPMC,infrared Spectroscopic analysis confirmed the better formulation of hydroxypropyl starch and corn starch composite film.At this time,the tensile strength of hydroxypropyl starch and corn starch composite film was 6.97 MPa,and the elongation at break was 24.28%.The amylose content ratio determines the preferred ratio of the hydroxypropyl starch to the amylose composite film.At this time,the tensile strength of the hydroxypropyl starch and the amylose composite film is 4.70 MPa,and the elongation at break is 21.90%.By studying the effect of different casting temperatures on the surface of the film,it was determined that the temperature at which the hydroxypropyl starch composite film was cast into a film was 60 °C.The properties of the three composite membranes were compared by analyzing the mechanical properties,solubility,particle size and transmittance of the starch composite membranes of the three different substrates.The results show the elongation at break of the hydroxypropyl starch composite membrane.The rate has obvious advantages,the solubility in acid is the best,and the light transmittance is optimal.The comparison of hydroxypropyl starch composite film has certain advantages in the three.From the comparison of the water absorption of the gelatin film,pure hydroxypropyl starch film,and hydroxypropyl starch composite film,it can be seen that the water molecule permeability of the hydroxypropyl starch composite film is lower,which is lower than that of gelatin film.The water-repellent properties of the starch-based hollow capsules were determined to be the hydroxypropyl starch composite film.The water property is determined to determine the preparation formula of the starch-based hollow capsule as a preparation formula of the hydroxypropyl starch composite membrane.Hydroxypropyl starch hollow capsules were prepared by using hydroxypropyl starch composite membrane formula.The tightness,friability and loss on drying of the prepared hollow capsules were tested to confirm that the prepared hydroxypropyl starch hollow capsules meet the requirements of Chinese Pharmacopoeia(2015 edition).