Photoinduced Redox-Responsive Poly(Se-P-P)@MOF Shell/Core Nanocomposite As An Effectively Controllable Drug Release System

As one of the vital approaches of cancer treatment,chemotherapy still has a very extensive range of clinical applications.Due to the non-specific toxicity caused by many chemical drugs,reasonably designed and controllable drug release system for cancer treatment has become a research hotspot.Here,we have designed a new intelligent light-controlled redox cleavage drug carrier.We have designed light/laserresponsive drug delivery nanoparticles by using photosensitive zirconium metalorganic framework(MOF)as the core and using ROS-responsive selenium(Se)containning copolymer as the shell.In detail,We first randomly polymerize bis-(1hydroxylendecyl)selenide(DH-Se)(Redox cleavable fraction),polypropylene glycol(PPG)and biocompatible polyethylene glycol(PEG)to form Poly(DH-Se/PEG/PPG urethane)(abbreviated as Poly(Se-P-P))polymer,and then apply it to the surface of porous zirconium metal frame(PCN-224 MOF)that can be capable of producing reactive oxygen species(ROS)by emulsion method to form the ultimate Poly(Se-P-P)@MOF spherical shell-core nanocomposite.Interestingly,we found that Poly(Se-P-P)@MOF nanoparticles loaded with anticancer drug doxorubicin(DOX)can perform rapid and controlled drug release under laser irradiation,and achieve the effect of combination therapy of photodynamic therapy and chemotherapy.This is because the MOF in the nanocomposite can generate a certain amount of ROS under laser irradiation,and then crack the Poly(Se-P-P)polymer wrapped on its surface via redox response,thereby releasing DOX encapsulated by polymer.To the best of our knowledge,this is the first design using selenium-substituted polymers and MOF as a controlled drug carrier,which may facilitate the combination of precise photodynamic therapy and chemotherapy,thereby greatly improving its anti-tumor effect.