Preparation Of Polyethylene Glycol-modified TiO₂ Nanotube Arrays And Its Drug Release

In recent years,titanium and titanium alloys have been developed rapidly,because of its strength,high hardness,low elastic modulus,high temperature resistance,corrosion resistance and biocompatibility characteristics,it is widely used in biomedical terms.But in practice,there are still shortcomings titanium and its alloys,such as biological activity is poor,difficult and bone firmly bonded together,prone to loose,there will be exclusion,and the metal surface will be ionized metal ions to produce toxicity.Because of these problems,so the need for titanium and its alloys surface modification.Studies have shown that generated by anodization on titanium surface layer of TiO2 nanotube arrays can enhance the biological activity of titanium metal and titanium metal and bone improve affinity,which helps combine titanium and bone,thereby enhancing the implant surgical success rate.TiO2 nanotube arrays with regular hollow structure,large specific surface area and good biocompatibility,since TiO2 nanotubes possess these properties,it has become one of the most promising nanomaterials,are widely used in local drug delivery system.Two different TiO2 nanotube arrays were fabricated by anodic oxidation in different electrolyte systems as a drug carrier in this paper.To explore the two different TiO2 nanotube arrays’s drug loading capacity and the ability to release.In this paper,the drug of choice is ibuprofen(ibuprofen,IBU),is a non-steroidal anti-inflammatory drugs,commonly used in clinical medicine in the treatment of pain,fever and inflammation and other diseases.First,by anodic oxidation in different electrolyte systems were prepared TiO2 nanotube arrays of two different morphologies,one is at the height of glycerol/water system ordered and prepared in close arrangement of TiO2 nanotube arrays(TNTs);one is lactic acid/dimethyl sulfoxide system prepared bassoon gap of TiO2 nanotube arrays(LTAs).In the model drug ibuprofen,by vacuum drying ibuprofen drug loading onto the TiO2 nanotubes conduct the study drug loading and release behavior in phosphate buffer solution(PBS)in.Hydrothermal method PEG nanoparticles supported on TiO2 nanotubes,to reduce the specific surface area and adsorption capacity of TiO2 nanotube diameter tubes and increased by PEG nanoparticles,thereby increasing TiO2 nanotubes and achieve anti-drug load release of the drug effect.The morphology and phase of TiO2 nanotube arrays were characterized by means of SEM,FTIR,XRD,UV-vis.Furthermore,by immersion method γ-glycidoxypropyl trimethoxysilane(GPTMS)grafted onto TiO2 nanotubes,GPTMS is a common silane coupling agent,GPTMS molecules in aqueous solution will react with water to generate Si-OH bond,after the Si-OH bond will generate Si-O-Ti bond with Ti-OH TiO2 nanotube array,while GPTMS molecule after hydrolysis of-OH ibuprofen drug molecules formed in-COOH the effect of chemical bond,GPTMS nanotubes after modification to have good biological activity,and increases the load and slows the release of the drug ibuprofen medicament.The morphology and phase of TiO2 nanotube arrays were characterized by means of SEM,FTIR and TG.