Study On The Synthetic Process Of Picoxystrobin

The function of pesticide in modern agricultural technology is becoming more and more important.The fungicide of Strobilurins has broad spectrum antibacterial,weak biological and ecological toxicity,and has a good effect on preventing and t-reating diseases,good effect for prevention disease and has a significant effect on increasing yield,and is safe for users,crops and environment.Picoxystrobin is a Strobilurins fungicide of great potential.With further study on the synthesis and a-pplication of technology,Picoxystrobin has a more broad application prospects in a gricultural production of our country.This dissertation is focused on process resear-ch synthesis of Picoxystrobin.In the present paper,synthetic methods of Picoxystrobin were reviewed in det-ail.With the disadvantages and advantages on the synthetic routes,design of a ne-w synthetic process for industrial production.(E)-Methyl-2-(methoxymethylene)-2-m-ethylbenzeneacetate was synthesized via esterification,ester condensation,methylati-on,chloration from o-Tolylacetic acid.Another intermediate 2-Hydroxy-6-trifluorome-thylpyridineenoate was synthesized via hydrolization from 2-Fluoro-6-trifluoromethyl-pyridineenoate.The Picoxystrobin was synthesized via etherification reaction from the above two intermediates.Under the optimal condition,the total yield was 44.2%based on o-Tolylacetic acid.and the purity was 98.26%.Meanwhile the proble-ms in each of the reaction and side reactions were studied and discussed.The syn-thetic process has some advantages of high yield,simple operation and high purity,and is suitable for industrial production.The chemical structures of Picoxystrobin a nd intermediates had been characterized by ~1H-NMR.