Study And Evaluation Of The Quality On Allopurinol Sustained-release Pellets

Gout is common disease in the population,it relates to race,food,alcohol,type of work,environment and cultural level and so on.In the European and American countries people have the disease probability between 0.2%and 1.7%.In recent years,domestic gout patients increased,the general population with the disease rate is about 1.14%.Allopurinol is the preferred drug for treatment of gout.Most of the domestic market sales allopurinal for ordinary tablet and sustained release dosage forms,this kind of dosage form has the problem with frequent dosing and absorb problem.So this article selected allopurinal as model drug sustained-release pellet preparation and prescription,and its in vitro drug release behavior were analyzed and discussed.To improve membrane type control allopurinal sustained-release pellet search for the prescription and manufacturing equipment,and complete quality evaluation,to study the in vitro drug release mechanism of pellet.The method of centrifugal granulation preparation of pellet,survey diluent,with main engine rate of revolution in the process of preparation of adhesives,the speed of spray for powder and the effect of speed on a pill,through study prescription and equipment,it improved prescription and equipment parameters,the resulting particle size(14～16 orders)in more than 80%,proportion of pellet harvest pellet surface smooth,similar size,hardness,good liquidity.Adopt the method of rotating coating for allopurinal pellet makes sustained-release coating,indicators,release degree Eudragit?NE30 can be used as coating material,the resistance to adhesive,coating weight,and factors such as heat treatment time,determine the Eudragit?NE30 some coating prescription.The prescription and preparation of selected device is reasonable and feasible,pellet gained by the good quality.