Research On Monetasone Furoate Nasal Spray With Thixotropic Fluid Properties

With the development of society and economy,the problem of environment and air pollution worsening,allergic rhinitis is becoming a common disease plaguing our daily life.The main symptoms of allergic rhinitis are nasal congestion,runny nose,sneezing and others,and a few common symptoms include headache,cough and itchy throat.Severe symptoms may also turn into sinusitis,asthma or ear infection.It has recurrent features,so more and more people pay attention to it now.Nasal corticosteroids are first-line treatment of allergic rhinitis medication,which can reduce body’s sensitivity to allergens,control or prevent symptoms onset from all aspects,and then reduce congestion and edema of the nasal mucosa.Mometasone furoate is a representative pharmaceutical glucocorticoid hormone.Mometasone furoate is a synthetic glucocorticoid hormone,has significant effect to clinical symptoms with little systemic side effects,which has anti-inflammatory and anti-allergic effects.Mometasone furoate nasal spray quickly takes action and controls nasal congestion,sneezing,runny and other allergic phenomena in the short term after treatment of nasal itching,and easy to carry and use.The mainly locats is the nasal mucosa so rare drugs ingest through nasopharynx,immune response is suppressed,and antibody synthesis is reduced.Nasonex,the original research product,is a new drug marketed by Merck by FDA in 1997.At present,there is no similar domestic drug producted.This article determined categories of accessory based on the prescription analysis of Nasonex,identified Avicel RC-59 as suspending agents depending on the indexes of viscosity,thixotropic,sedimentation volume ratio mmol osmotic pressure compared with Nasonex.Thus we obtained Mometasone furoate nasal spray prescription;spray pump model what we chose was NPS-20E,though quantitative spray pump spray volume size,spray pattern and spray by the geometry of Nasonex.The paper established determination method of main drug Mometasone furoate and antiseptic Benzalkonium chloride and conducted methodological research.Then we finished the establishment of related substances detection methods.Factors experimental results showed that mometasone furoate nasal spray in strong sunlight,high temperature and high humidity were stable;the results of acceleration and long-term test showed that the samples did not change significantly within six months.By nasal irritation test in rabbits and guinea pigs allergy tests to investigate the special security Mometasone furoate nasal spray,animal studies showed that Mometasone furoate nasal spray did not have sensitization and irritation,so drugs are safe and reliable.