| In recent years,medical textile materials with functions of information transmission and health detection have become a research hotspot in the textile field.The pH-responsive antimicrobial fabric has dual functions of acid-base change indicator and antimicrobial,and can be used in medical dressing.At present,most of the indicators used for pH response monitoring are chemical synthetic dyes,which have potential safety threats to human body.In addition,problems such as bacteria breeding will occur when a single pH response fabric is applied to the wound.This topic in wood pigment for pH indicator,with chitosan,sodium alginate,isinglass protein and levofloxacin hydrochloride as main nanometer fiber membrane materials,using multilayer self-assembly technology combines fabric and nano fiber membrane,the preparation of pH response discoloration,moisturizing and antibacterial function of threelayer composite fabric,for the development of pH response type medical dressings to provide a solution.The first layer of the fabric is the pH response layer,which is used to monitor the pH value of the wound exudate(the relevant data shows that the wound is inflamed when the wound pH? 7).The layer is composed of hematoxylon dyed cotton fabric.The discoloration of hematoxylon pigment and its dyed fabric at different pH values was tested by ultraviolet and visible light spectrophotometer and fabric color meter.The results showed that the color of hematoxylon pigment changed from yellow to red when the pH value increased from 3 to 10.Dyed fabric in environmental pH value increased from 6 to 7,the maximum absorption wavelength near from 450 nm to 550 nm,chromatism ? E more than 8.0,the color changed from yellow to red,the color response time < 20 s.The color domain of cotton fabric dyed with hematoxylon meets the requirement of wound monitoring,and the color effect can be seen with naked eyes.The second layer is hygroscopic,providing a moist environment for healing.The electrospun nanofiber film was prepared with polyvinyl alcohol and sodium alginate as raw materials,and the binding fastness to the first layer was improved by cross-linking treatment.The raw material ratio and spinning process parameters were optimized.The structure and properties of the fiber films were characterized by SEM,FT-IR,XRD,DSC,TG,contact Angle and EDS energy spectrum.The results showed that the optimal ratio of raw materials was 7:3 between10% PVA and 2% sodium alginate.The optimal process parameters are 12 k V voltage,20 cm receiving distance and 0.5 m L/h propelling speed.At this time,the fiber diameter is 90 nm,and the diameter CV value is 16.37%.In 3s,the contact Angle drops > 20°,and the instantaneous hygroscopic performance is good.The nanofiber membrane was crosslinked with the first layer.The third layer is antimicrobial layer,used to inhibit bacterial reproduction.The layer is a drug-carrying nanofiber membrane with chitosan,fish collagen and PEO as raw materials and levofloxacin as antibacterial agent.Minitab software was used to optimize the ratio of spinning raw materials,and orthogonal experiment was used to optimize the spinning process parameters.The structure and properties of the fiber films were characterized by SEM,FT-IR,DSC,contact Angle,EDS,XRD and antimicrobial tests.The results showed that the optimal raw material ratio was 45% chitosan,45% fish collagen and 10% PEO,and the optimal spinning process parameters were as follows: voltage 12 k V,receiving distance 20 cm,propellant speed 1.5 m L/h,fiber diameter 264 nm and diameter CV value 14.51%.When the content of levofloxacin in 2% was 15%,the fibrous membrane had good antibacterial effect on Escherichia coli and Staphylococcus aureus. |
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