Preparation And Study Of ?-cyclodextrin Derivative Cross-linked Copolymer

?-cyclodextrin is a kind of cyclic complex with good biocompatibility.A large number of active hydroxyl groups in its structure can be modified by surface modification to prepare copolymer materials with different functions,which are widely used in different fields.This topic uses?-cyclodextrin derivative to obtain copolymers with different hydrophilicity and hydrophobicity through radical polymerization and ring-opening reaction.Subsequently,using the self-assembly method,redox radical polymerization and complexation reaction,?-cyclodextrin copolymer/acetylsalicylic acid inclusion complex,dual-sensitive?-cyclodextrin hydrogel and?-cyclodextrin metal complex hydrogel were prepared respectively.The functionalized?-cyclodextrin derivative was synthesized by sequentially carrying out esterification reaction and amidation reaction on?-cyclodextrin,and then undergoing radical polymerization with styrene and butyl methacrylate to obtain an amphiphilic copolymer.Then,the?-cyclodextrin copolymer/acetylsalicylic acid inclusion complex was prepared by the self-assembly.The structure of the product was verified by infrared spectrum and nuclear magnetic hydrogen spectrum.The test results of differential scanning calorimetry and X-ray diffraction method proved that the inclusion complex was successfully prepared.Through thermogravimetric analyzer and contact angle measuring instrument to study the thermal stability and hydrophilicity and hydrophobicity of copolymer and inclusion complex,it is found that both have good thermal stability and amphiphilic performance.The slow-release performance and anti-bacterial adhesion performance of the inclusion complex were analyzed through ultraviolet spectroscopy and antibacterial experiment.The results show that the inclusion complex can slowly release acetylsalicylic acid which in the cavity after changing environmental conditions.After reaching equilibrium,the concentration of acetylsalicylic acid in the solution can reach up to 52.5?g/m L.When the inclusion complex was introduced into the polystyrene system,as the amount of the inclusion complex gradually increased,the amounts of bacteria adhered to the surface of the blend sheets would gradually decrease until the minimum adhesion amounts was reached.Using?-cyclodextrin derivative,cholic acid and epichlorohydrin as monomers,a hydrophilic copolymer was prepared by a ring-opening reaction.It was polymerized with acrylic acid and N-isopropylacrylamide monomers to obtain?-cyclodextrin hydrogel through redox radical polymerization.The structure of the product was verified by infrared spectrum and nuclear magnetic hydrogen spectrum.The T_g and endothermic peak of the hydrogel were studied by differential scanning calorimeter.The surface morphology of the hydrogel was analyzed by scanning electron microscope.The thermal stability of the copolymer and hydrogel was detected by a thermogravimetric analyzer,and the results show that the thermal stability of the hydrogel was improved compared to that of the copolymer.The swelling experiment was used to study the temperature sensitivity,p H sensitivity and water retention rate of the hydrogel.The hydrogel and acetylsalicylic acid were prepared by the self-assembly principle to obtain the hydrogel inclusion complex,and its sustained release performance was studied by ultraviolet spectroscopy.The results show that the hydrogel inclusion complex can slowly release acetylsalicylic acid,and the equilibrium concentration of acetylsalicylic acid in the solution can reach73.62?g/m L.Using?-cyclodextrin copolymer,acrylamide and N-isopropyl acrylamide as monomers,?-cyclodextrin hydrogel was prepared by redox radical polymerization.Then,it reacted with copper ions to obtain?-cyclodextrin metal complex hydrogel.The structure and composition of the product were characterized by infrared spectrum and elemental analysis.The surface morphology of hydrogel and metal complex hydrogel were studied by scanning electron microscope.The thermal stability of hydrogel and metal complex hydrogel were tested by thermogravimetric analyzer.The results show that both have good thermal stability,and the thermal stability of the complexed hydrogel has been improved.The temperature sensitivity of the metal complex hydrogel was analyzed and discussed through the swelling experiment.The adsorption performance and frost resistance performance of hydrogel and metal complex hydrogel were studied by adsorption experiment and frost resistance experiment.Among them,the ultraviolet test results found that the metal complex hydrogel can show better adsorption performance for copper ions after being washed completely,and its maximum adsorption capacity was 19.39 mg/g.The metal complex hydrogel has good frost resistance performance through frost resistance experiment,that is,it can resist frost continuously for 8 h at-18?.