Study On Inorganic/Organic Bioactive Coatings On PE And PET Fibers

In recent years,with the rapid development of medical technology,the market demand for biomedical materials is also increasing,and the application of biomedical materials in human social life is more and more extensive.Medical polymer materials have a good performance in the field of medicine,but due to the limitation of biocompatibility on the surface of materials,improving the biocompatibility of materials is one of the focuses of current research on medical polymer materials.In view of this problem,this project intends to develop a kind of ultra-high molecular weight polyethylene(UHMWPE)and polyethylene terephthalate(PET)material,and conduct surface modification to improve their biocompatibility and hydrophilicity so that they can meet the clinical needs.Specific research results are as follows:(1)This topic to the PE material surface using silk fibroin(SF)on the modification,preparation of a kind of good hydrophilicity and cell adhesion behavior of silk fibroin grafted material,and using the Fourier transform infrared spectroscopy(FT IR),scanning electron microscope(SEM),thermogravimetric(TG)and water contact Angle analysis methods such as chemical structure of PE/SF composites,and characterization of the hydrophilic and morphology.The results showed that SF could form a coating on the surface of UHMWPE,and the use of chromic acid corrosion was more conducive to SF deposition.After chromic acid corrosion,the surface hydrophilicity and SF deposition of UHMWPE material were improved,so that the SF coating amount reached 10.31%.Moreover,the mechanical properties of UHMWPE material did not decline significantly,indicating that the SF deposited on the surface of UHMWPE material had no effect on its mechanical properties.The experiment of cell adhesion degree of UHMWPE material showed that PECr SFs material had the greatest cell activity,indicating that it had the best biocompatibility.(2)in this study,a new biocompatible PET braided mesh covered by zinc oxide(Zn O)/ tetrachalcium phosphate(TTCP)/ gelatin(Gel)coating was prepared by atomic layer deposition(ALD)and hydrothermal method,and the PET braided mesh coating was characterized by XRD and SEM.XRD results show that both Zn O and TTCP have good coatings on the surface of the PET braid mesh,and Zn O prepared by atomic layer deposition can make the adhesion of the coating reach about 8Mpa.The diameters and morphologies of Zn O,TTCP and gel of PET woven mesh were observed by scanning electron microscopy(SEM).After Zn O,TTCP and gel treatment,water contact Angle on PET surface decreased.Through confocal imaging of NIH3T3 cells,the obtained product was found to have the effect of promoting cell proliferation,indicating that the PET/Zn O/TTCP/Gel woven fabric prepared has good biocompatibility.Through the modification of PE and PET materials,the PET/Zn O/TTCP/Gel woven structure with the function of promoting cell proliferation and the UHMWPE/SF composite scaffold with good biocompatibility were obtained,indicating that surface modification on biomedical scaffolds is an effective way to obtain suitable hydrophilic surface,laying a foundation for its future application.