Study On Tandem Cyclization Reaction Between Thioaurone With MBH Carbonate Based On Isatin

MBH carbonate derived from isatin has proved to be a suitable precursor for the synthesis of many heterocyclic and biologically active molecules.It has great research value and potential in the tandem reaction.After the great efforts of chemists in recent years,the tandem cycloaddition reaction of MBH carbonate derived from isatin has been developed in many ways.In addition,thioaurone has different reaction modes for the construction of benzothiophene compounds.The main work of this paper is the synthesis of a penta-substituted cyclopentane with a double spiro ring structure by the tandem cyclization reaction between thioaurone and isatin-based MBH carbonate.The main work is divided into the following aspects:1)Using substituted thiophenol as the initial raw material to synthesize a series of thioaurone,under the catalysis of DMAP and MBH carbonate derived from isatin through tandem cyclization reaction to generate a five-substituted ring with double spiro rings pentane.2)On the basis of the previous article,the thioaurone analogue was changed,the NHTS was replaced with a hydroxyl group,and the reaction with MBH carbonate derived from isatin under the catalysis of DMAP was also obtained in a relatively good yield.In the other five-substituted cyclopentane,the dihydropyrrole ring in the molecule becomes a dihydrofuran ring.The moderate to good reaction yield makes the synthesis of penta-substituted cyclopentane compounds of potential application value.