Synthesis Of Near Infrared Light Responsive Nanomaterials And Synergistic Anti-tumour Properties

In recent years,cancer has become a major disease affecting the safety of human life.Its high mortality and low cure rate make people talk about cancer.The treatment of cancer mainly includes surgery,chemotherapy and radiotherapy.But they generally have the shortcomings of low treatment efficiency and large side effects.Therefore,it is very important to develop efficient and safe cancer treatment methods.With the continuous development of science and technology,the emergence of nanotechnology provides more ideas for anti-tumor treatment.Among them,the development of safe and effective nano photosensitizer for optical therapy has attracted extensive attention.At present,optical therapy mainly includes photodynamic therapy(PDT)and photothermal therapy(PTT),that is,after drug injection,laser irradiates the tumor site to produce reactive oxygen species(ROS)and heat,so as to kill tumor cells and achieve anti-tumor treatment.In the process of optical therapy,the selection of appropriate light source becomes the key.Compared with ultraviolet and visible light,near-infrared light has the advantages of less damage and strong tissue penetration,which is the main light source for optical therapy.As an alternative to traditional therapy,chemokinetic therapy(CDT)can produce cytotoxic · Oh through Fenton reaction,which can induce tumor cell death without damaging normal tissue.At the same time,CDT can overcome the disadvantage of poor light transmittance in deep tissue because it does not need excitation light source in the process of treatment.It can kill tumor cells more effectively.Synergistic anti-tumor therapy can integrate the advantages of various treatment methods and improve the anti-tumor performance.Based on this,optical materials sensitive to near-infrared light were synthesized to study the synergistic anti-tumor therapy.The specific research contents are as follows:(1)First,we synthesized Bi@PVP Then,carbon coated Bi nanocomposites were prepared by solvothermal method using citric acid and urea as carbon sources(Bi@C).The coating of carbon layer not only improves the stability of Bi nanoparticles,but also shortens the distance between Bi nanoparticles,enhances the LSPR effect,enhances the near-infrared light absorption ability,and exhibits a high photothermal conversion rate(52.3%).In addition,NIR light can generate hot electrons and ROS to realize photodynamic therapy.In addition,the attached antitumor drug(DOX)showed the drug release ability of acid / photothermal response.So far,CT / PT imaging combined with PDT / PTT / chemotherapy has made the nanomaterials have good biodegradability Bi@C@PEG-DOX The nanoparticles show excellent anti-tumor properties.(2)CuPc-1 and C-3 with high absorption capacity were prepared by hydrothermal method with copper phthalocyanine as raw material.The two are combined to obtain CuPc/C NPs,because ?-? The accumulation effect,the decrease of fluorescence intensity of cupc/c NPs is conducive to the improvement of PTT and PDT performance,and the fl/pt imaging guided pdt/ptt can be used in the treatment of anti-tumor.(3)Fe-CuPc nanomaterials were synthesized by doping iron ions.The material has Fenton property and can produce CDT effect.The results of in vitro test show that the PTT and PDT ability of the materials are improved.Therefore,Fe-CuPc has the potential to be a nano system for PTT / PDT / CDT combined therapy.