Copper-based Nanomaterials For Enhanced Chemodynamic Therapy

In recent years,chemodynamic therapy(CDT)has attracted more and more attention,because of its high tumor selectivity,which can transform the overexpressed hydrogen peroxide(H₂O₂)into highly toxic hydroxyl radical(·OH)to kill tumor cells through Fenton or Fenton-like reaction.However,due to the complexity,heterogeneity and insufficient H₂O₂ reactivity of tumor regions,the further clinical application of CDT was limited.Therefore,it's an urgent problem to enhance the therapeutic effect of CDT.Based on such scientific problem,this programe designed kind of high-performance CDT reagents to improve the therapeutic effect of CDT by combination of the increase in number of active sites and photothermal performance.The following are two parts of work:The first part:based on the principle that hollow nanomaterials can increase the reaction sites and the reaction rate can be accelerated by the increasing temperature,we constructed a hollow Cu₉S₈ nanometer diagnosis and treatment platform,which not only has the functions of photoacoustic imaging(PAI)and photothermal therapy,but also can increase the number of active sites for catalytic reaction.The solution experiment results showed that the specific surface area of the Cu₉S₈ nanometer platform was significantly increased,and its photothermal conversion function could effectively increase the Fenton-like reaction temperature,making the rate of the formation of·OH about twice that of the solid Cu₉S₈ nanometer material,significantly increasing the Fenton-like reaction efficiency.More importantly,in vivo and in vitro experiments have proved that hollow Cu₉S₈ nanometer diagnostic platform has more excellent CDT therapeutic performance,which can effectively kill tumor cells and inhibit tumor growth.The second part:based on the principle that high temperature and single atom are beneficial to improve the efficiency of catalytic reaction,a nano-diagnosis and treatment platform Fe@Fe₃O₄@HKUST-1 was built in this project.Fe@Fe₃O₄nanomaterials have excellent magnetic heating properties and magnetic resonance imaging(MRI)properties,which can improve the temperature of Fenton or Fenton-like reaction in situ and speed up the reaction rate,while the metal shell frame HKUST-1can release copper ions,showing a single atomic catalytic performance,improving the Fenton-like reaction performance.The results showed that Fe@Fe₃O₄@HKUST-1exhibited a synergistic effect of"1+1>2",which showed better Fenton like catalytic performance than that of single Fe@Fe₃O₄NPS and HKUST-1 NPS.