Preparation And Properties Of Amphiphilic Fluorocopolymer Based On ROMP

Amphiphilic polymer,both hydrophilic and hydrophobic components,can largely weak the microbes in the adsorption on the material surface caused by the interface effect.Although some progress has been made in the research of amphiphilic polymers,the diversity and complexity of biological attachment has led to still some problems to be solved in practical applications.In this paper,different hydrophilic/hydrophobic monomers and a series of amphiphilic fluoropolymers were obtained based on molecular design and the relationship among the material chemical composition,microstructure,wettability,antifouling property and mechanism were studied,in order to obtain materials with excellent mechanical properties and anti-protein adsorption properties,and provide new ideas and methods for in-depth disclosure of the anti-fouling mechanism of amphiphilic polymers.This paper adopted norbornene fluoroalkyl ester as hydrophobic component and norbornene polyethylene glycol ester and norbornenyl betaine sulfonate amphoteric ions as hydrophilic components.Amphiphilic fluoropolymers were prepared by ring-opening metathesis polymerization.The influence of the proportion and type of hydrophilic and hydrophobic components on the anti-protein adsorption performance and the anti-protein adsorption mechanism of the amphiphilic fluoropolymer was studied.The results show that with the increase of hydrophilic component content,the anti-protein adsorption effect on the surface was obviously enhanced,at the same time,the mechanical properties were improved.When the content of polyethylene glycol is 50%,the adsorption amount of bovine serum albumin(BSA)on the surface was less than 20μg/cm~2,and the adsorption amount of fibrinogen(Fg)was less than 25μg/cm~2;and in the water-swollen states,the tensile strength of polymer membrane(PNPFE-PEG-50%)was still 8 MPa,the elastic modulus can reach 200MPa,and the elongation at break was 74%.On the surface containing 92%norbornenyl-sulfobetaine zwitterion(PNPFA-DAPESB-92%),the adsorption amount of BSA was 9.82±1.59μg/cm~2,and the adsorption amount of Fg was 11.03±2.40μg/cm~2,and after three cycles of adsorption-desorption,the protein absorption resistance of the surface remained stable.Meanwhile,the tensile strength was 5 MPa,the elastic modulus was 12 MPa,and the elongation at break was 445%.Through the study of the surface chemical composition microstructure and wettability,the importance of the anti-protein adsorption performance is the surface microstructure and dynamic recombination phenomenon.The existence of hydrophilic/hydrophobic components and the nonuniform nano-heterogeneity of the amphiphilic surface provide a spatial barrier effect and topographical shelter for the adhesion of proteins,thereby imparting protein resistance to the material surface.