The Synthesis Of Acridine And Pyridazine Derivatives

In recent years,as the molecular structure unit of drugs,nitrogen-containing heterocyclic ring has been a hot topic in the field of synthesis research,and it has attracted much attention due to its physiological and pharmacological activities.In this paper,green synthesis methods of acridine and dihydropyridazine derivatives were studied from the perspective of environmental protection.The research results obtained are as follows:The addition/cyclization reaction of 2-aminophenyl benzonitrile with aromatic boric acid catalyzed by palladium was studied to produce 9-aryl acridine derivatives.In this method,phenylboric acid was used as arylation reagent in tandem reaction with 2-aminophenyl benzonitrile to construct acridine derivatives.On the basis of producing intermediate ketone,9-aryl acridine derivatives were further cyclized.The method has the advantages of easy availability of raw materials,simple operation,high yield,wide expansion and universality of substrates,green solvent water as reaction condition,and environmental friendliness.We studied the synthesis of 1,6 dihydropyridazine derivatives on hydrazone with the catalytic oxidation of and-unsaturated inner ring by I2.In this method,the olefin is activated by molecular iodine and hydroamination occurs.The main features of this synthesis method are short reaction time,mild conditions,high atom utilization rate,and the use of metal-free green catalyst molecular iodine,which can be synthesized efficiently and reduce the harm to the environment at the same time.