Research On The Construction And Application Of Intelligent Diaper Sensing System

With the aging of China's population,the proportion of elderly people with language and physical disabilities in the total population is increasing.These older people also usually need regular urinalysis to estimate chronic disease,such as urinary incontinence,diabetes,and gout.Concentration levels of related disease markers in the urine are an important basis for physicians to diagnose the disease and determine its effectiveness.In hospitals,patients have to take their own samples,and inspectors rely on urinalysis equipment for urinalysis and analysis.This detection method is very difficult for the elderly with urinary incontinence.Such people usually need to wear adult diapers to solve the problem of incontinence.In response to the above problem,in this paper,we researched a smart diaper sensing system that combines a biosensor embedded in the diaper,and design a detection device that can obtain sensor signals to realize online detection of disease markers in urine,and use wireless communication modules to send the detection results to the smartphone App.Clinicians,nurses and patient family members can view the test results on their mobile phones at any time after authorization.The research content of this article mainly includes:(1)A glucose and uric acid sensor based on polyethylene terephthalate(PET)was prepared.The tetrathiafulvalene(TTF)as an electronic mediator to modify the working electrode,and the Oxidase(GOD)or urate oxidase(UOD)was immobilized on the working electrodes by glutaraldehyde(GA).In addition,a self-expanding "valve" is proposed to control the amount of urine entering the sensor.The detection device was used to obtain the sensor signal,and the device was mainly consisted of the microprocessor,operational amplifier,power module,wireless communication module,OLED display module.Through the 2.5 V power chip output the voltage accuracy within±1%,which is used as the virtual ground of the constant potential circuit and the analog-to-digital converter(ADC)reference to ensure the accuracy of the detection device.At the same time,the connection circuit of the constant potential circuit,the signal acquisition and conditioning circuit,the wireless communication module and the display module are designed.(2)The lower computer program of the detection device and the Android-based smart phone App software were developed,and the server platform cooperate with the App was built.The cyclic voltammetry and chronoamperometry implementation programs of the detection device are written in C language.The voltage scan rate can reach 1.2 mV/s and the sampling interval is 0.1 s.The noise in the original signal is removed by the moving average filtering procedure.The signal is processed by the main control chip,the detection result is calculated,and displayed on the OLED screen.Synchronously,the detection result is sent to the smartphone App by the wireless module in the detection device.The main functions of the App include user registration and login,wireless connection with detection devices,wireless reception of detection results,data visualization and local storage,data upload to the database in the server and remote online query of detection results.Based on the SpringBoot framework and Java language,the program of the server platform based on windows is written to realize the remote storage of detection data;authorized users such as clinicians,nurses in charge,and family members can use the App to view the detection results online in different places.(3)The performance test and application research of the smart diaper sensor system are carried out.The detection device and the electrochemical workstation CHI660E under the same detection method and parameter settings,carry out the redox test experiment of potassium ferricyanide-potassium ferrocyanide solution,and compare and analyze the detection data by the Bland-Altman method.The results show that the performance of device is close to CHI660E.The performance test experiment of the biosensor for glucose and uric acid was carried out.The results showed that the sensitivity of the sensor for glucose in the range of 0-20 mM and uric acid in the range of 0-0.8 mM was 0.0582 ?A/mM and 1.5043 ?A/mM,respectively.The correlation coefficients are all above 0.92,indicating that the sensor has high sensitivity and linearity.In addition,the anti-interference experiment of the biosensor was also carried out,and the results showed that the two sensors still showed good selectivity and anti-interference in the presence of interference substances such as ascorbic acid and potassium chloride.Finally,the actual test experiment with volunteers wearing smart diapers verifies the feasibility of the main functions of the sensor system.