Coating Design Based On Multi-objective Optimization And Its Impact Study On Neural Electrode Surface Performance

In the nervous system,neurons transmit signals by electrical signal transmission.The implantable neural microelectrode is a major component of neural prosthesis and brain-computer interface system.It is capable of collecting and recording bioelectrical signals generated by nerve cells,and applying electrical stimulation to nerve tissue,with which monitoring and control of neural activities could be achieved.In this way,neurological functional diseases could be prevented and treated.In neural microelectrode structure,the site interconnects electrically with the nerve tissue.Its performance directly affects the work quality and service life of the electrode.Preparation of coatings at electrode sites is often used to improve and optimize their electrochemical performance.How to effectively improve the charge storage capacity and reduce electrochemical impedance through the selection of coating materials and the design of the preparation process with the extremely limited site size is a problem that has attracted much attention in the research of neural microelectrode.In this work,a new coating preparation method was proposed.It combined material selection,surface microstructure design and surface functionalization treatment.The aim of this work is improving the electrochemical performance and its stability of the neural microelectrode,optimizing the preparation method of the electrode coating,as well as enriching the functionality of the electrode.In this paper,an oriented electrodeposition method and graphene oxide modification were used to prepare the coating on the surface of platinum electrodes.With cyclic voltammetry test and electrochemical impedance spectroscopy,it is verified that the coating preparation method greatly improved the double-layer capacitance and cathode charge storage capacity of the platinum electrode,reduced its electrochemical impedance and changed the charge transfer mode.The optimization of these properties has also been shown to have mechanical and electrochemical stability.At the same time,how the experimental conditions of the oriented electrodeposition process influenced electrode performance was studied.The relationship between the hydrophilicity of the electrode surface and its electrochemical performance were also studied.Micro-electromechanical system processing flow of neural microelectrode and preparation method of antifibrotic drug-loaded coating were also proposed in this work.The combination of these methods is a complete manufacturing process of a multifunctional and high-performance neural microelectrode.