Study On Auto-oxidation To Constuct 6-Membered N-Containing Heterocycles

This thesis is divided into three parts and mainly introduces the cyclization reaction of amines.The first part reviews the synthesis progress of isoquinoline-1,3(2H,4H)-diones and indoles by employing N-methacrylbenzamide and N-arylacrylamide as substrates respectively in recent years.The contents include two aspects:(1)the construction of C-C bonds;(2)the construction of C-X(X=N,P,S)bonds.In the second part,we develop an auto-oxidative tandem radical cyclization of N-methacryloyl benzamides with CBr₄ to construct brominated isoquinolinediones for the first time.The strategy also presents a new way to generate bromine radicals under mild conditions.In the third part,we develop an auto-oxidative Povarov/aromatization tandem reaction of glycine derivatives with enamides for the construction of a series of quinoline compounds.It is worth noting that the acetamino group is employed in this transformation as both activating and leaving group to improve the reaction efficiency.