The Study Of Metal-Catalyzed Asymmetric Ring Opening Reaction Of Cyclic Triacylamines

Synthesizing chiral compounds plays important role in organic chemistry and medicinal chemistry.The strategy of desymetarization is widely used in synthesizing chiral compounds.In this dissertation,chiral amide esters have been obtained via asymmetric desymetarization strategy.After evaluating the chiral ligands,metal catalysts,solvents,temperature,additives and nucleophiles,we found that the yield and enantioselectivity of this reaction highly depended on the substrate structure.Although the yield of several products is moderate,the best enantioselectivity still be up to 90% among the experimental results.To some extent,this reaction broadens the application of the triacylamines in asymmetric catalysis,and also provides a new method to synthesize chiral bifunctional amide esters.