Synthesis Of Cylindrical Polymer Brushes And α-cyclodextrane Polyrotaxanes

Nano carriers for anticancer drugs can enhance the therapy effectiveness and reduce unwanted side effects of drugs through improving their biodistribution and tumor accumulation.In this work,we synthesized cylindrical brushes,star-shaped brushes andα-cyclodextrane polyrotaxanes as potential drug delivery carriers,and developed new methods for synthesizing star-shaped brushes and α-cyclodextrane polyrotaxanes.The main contents are as follows:1.The cylindrical brushes with poly(y-3-chloropropanyl-L-gluamate)as main chain and PEG as side chain were synthesized by the ring-opening polymerization of y-3-Chloropropanyl-L-glutamic Acid Based N-Carboxyanhydride followed by nucleophilic substitution reaction and Cu(Ⅰ)-catalyzed alkyne-azide 1,3-dipolar cycloaddition(CuAAC).AFM observations demonstrated the the worm-like shape of the cylindrical brushes.This type of brushes have great application potentials in drug delivery due to their high hydrophilicity and good biodegradability.2.Star-shaped poly(y-3-chloropropanyl-L-gluamate)was synthesized through the ring-opening polymerization of y-3-Chloropropanyl-L-glutamic Acid Based N-Carboxyanhydride with PAMAM(generation 1)as a core molecule.Thereafter,star-shaped brushes with poly(y-3-chloropropanyl-L-gluamate)as main chain and PEG as side chain were synthesized through nucleophilic substitution reaction and Cu(Ⅰ)-catalyzed alkyne-azide 1,3-dipolar cycloaddition(CuAAC).Their morphological structure was examined by AFM.This work provides a alternative method for synthesizing the star-shaped brush.3.A new method for synthesizing α-cyclodextrane polyrotaxane was primarily developed by using the triazole rings formed in CuAAC as end-capping groups.