Brain Network Connectivity In Juvenile Myoclonic Epilepsy

In this paper,we explored the abnormal changes of brain network in Juvenile myoclonic epilepsy(JME)patients by studying brain network connectivity.Abnormal changes in brain networks were caused by abnormalities in the core brain region,so the focus of this paper was the core brain region.Through the processing and analysis of structural image MRI data and functional image f MRI data,the core brain regions were identified and verified.Voxel-based morphological analysis(VBM)was used to investigate the structural differences between JME patients and normal controls.The gray matter volumes of the two groups were obtained by VBM analysis.The difference of gray matter volume between the two groups was analyzed by two-sample T test.Three different brain regions were determined,namely,right middle frontal gyrus,left parahippocampus gyrus and left precuneus.The three different brain regions were selected as the studied brain regions with effective connectivity.Granger Causality Analysis(GCA)model was used to study the effective connectivity between the three different brain regions of the two groups of subjects,and to explore the interaction between the three different brain regions.The time series of the three brain regions were extracted to construct the Granger causality analysis model based on the brain regions,and the Granger causality coefficients between the brain regions were obtained.Then six groups of causality were obtained through the two-sample T test.In a three-region pathway,right middle frontal gyrus negatively activated left parahippocampus gyrus,and right middle frontal gyrus negatively activated left precuneus.The results showed that right middle frontal gyrus activated the other two brain regions and inhibited the information transmission between brain regions.Therefore,the right middle frontal gyrus is presumed to be the core brain region of JME disease.The correctness of right middle frontal gyrus was obtained by effective connectivity was verified by functional connectivity study.First,the brain functional networks of the two subjects groups were constructed.Then,each attribute index of the brain functional networks were calculated,and carried on comparative analysis.The results showed that the global efficiency and local efficiency of the brain network in the normal control group were higher than those in the JME group,suggesting that some functional connectivity failures occurred in the brain network in the JME group.In the end,right middle frontal gyrus was used as the core of the sequential fault analysis.The specific operation was to take right middle frontal gyrus as the core node and attack the core node through successive failure model.After the attack,the attribute indexes of the two groups of functional networks were calculated again.The results showed that the average local efficiency and average global efficiency of the two groups of functional networks were very similar after the attack.Therefore,the verification of right middle frontal gyrus plays a very important role in the research of JME disease and needs to be focused on.