Research On The Construction And Performance Of Composite Metal Multifunctional Nanometer

Since the discovery of antibiotics,bacterial infections have been effectively treated,but due to human abuse of antibiotics,excessive dependence on antibiotics has led to an increase in bacterial resistance.For example,the infection caused by Staphylococcus aureus is better controlled by the use of penicillin,but with the use of penicillin,Staphylococcus aureus produces penicillinase to decompose the?-lactam ring of penicillin,and then scientists study A semi-synthetic penicillin that can resist this penicillinase,namely methicillin.Also because of the continuous use of antibiotics,a methicillin-resistant Staphylococcus aureus(MRSA)has appeared in Staphylococcus aureus,and there is no better control method so far.In the upcoming crisis of antibiotic resistance,the task of finding antibacterial agents that can be used to resist them has become more and more urgent.Therefore,scientists are committed to finding an antibacterial agent that does not produce drug resistance.At present,the research of new antibacterial agents includes photothermal antibacterial(PTT),photodynamic antibacterial(PTA)and so on.The main researches in this paper are:CuInS₂@Bi₂S₃/pg-C₃N₄ compound antibacterial agent was prepared for the first time in the sterilization experiment of Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus.An intermediate layer conversion strategy was used to prepare a sea urchin-like CuInS₂@Bi₂S₃ core-shell structure.This method shows high active oxygen generation capacity and excellent photothermal conversion performance,and at the same time it was loaded on pg-C₃N₄ for capture Bacteria assisted sterilization.CuInS₂ and Bi₂S₃have been tested and found that their band gaps are 0.51 e V and 0.84 e V,and they have good light absorption in the near infrared region.The combination of CuInS₂ and Bi₂S₃can improve the separation efficiency of electron-hole pairs triggered by near-infrared light,leading to the production of a large amount of active oxygen and showing enhanced antibacterial ability.CuInS₂@Bi₂S₃/pg-C₃N₄ has considerable light-to-heat conversion efficiency,which can reach 43.12%.After CuInS₂@Bi₂S₃/pg-C₃N₄composite antibacterial was irradiated by near-infrared laser(808 nm,0.5W/cm²),due to its synergistic photothermal and photodynamic antibacterial(PTA/PDA)performance,it is effective against Escherichia coli and Staphylococcus aureus.The sterilization rate is as high as 99%.The effect of CuInS₂@Bi₂S₃/pg-C₃N₄ composite antibacterial agent on wound healing was further explored.The results showed that CuInS₂@Bi₂S₃/pg-C₃N₄ composite antibacterial agent can not only remove bacteria from the wound,but also promote wound healing.