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Acute effects of the antibiotic streptomycin on neural network activity and pharmacological response

Posted on:2015-10-13Degree:M.SType:Thesis
University:University of North TexasCandidate:Zeng, Wei RongFull Text:PDF
GTID:2474390017997686Subject:Biology
Abstract/Summary:
The purpose of this study is to find out that if antibiotic streptomycin decreases neuronal network activity or affects the pharmacological responses. The experiments in this study were conducted via MEA (multi-electrode array) technology which records neuronal activity from devices that have multiple small electrodes, serve as neural interfaces connecting neurons to electronic circuitry. The result of this study shows that streptomycin lowered the spike production of neuronal network, and also, sensitization was seen when neuronal network pre-exposed to streptomycin.
Keywords/Search Tags:Streptomycin, Network, Activity
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