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Public attitudes toward the ACMG guidelines regarding incidental findings arising from whole genome sequencing: an online survey

Posted on:2015-01-10Degree:M.SType:Thesis
University:Icahn School of Medicine at Mount SinaiCandidate:Fierro, LucaFull Text:PDF
GTID:2473390017988887Subject:Biology
Abstract/Summary:
The use of whole genome sequencing (WGS) in the clinical setting is constantly increasing. Whole genome sequencing inevitably discovers incidental findings. Following the publication of the ACMG recommendations (Green et al., 2013) a lively debate within the genetics community has tried to address the question of returning these incidental findings to patients, but little is known about patients' preferences. This study employed an online anonymous survey to explore the general population's attitudes toward whole genome sequencing and related incidental findings using hypothetical scenarios. A sample of the general population was recruited through the use of two social network pages (N = 118). The majority of respondents had positive attitudes toward whole genome sequencing and the return of possible related incidental findings. This study also demonstrated a relationship between previous exposure to genetics issues and people's preferences for the return of incidental findings from clinical whole genome sequencing.
Keywords/Search Tags:Whole genome sequencing, Incidental findings, Genetics
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