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The Vinylogous Aldol Reaction of Furoate Esters and the Synthesis of Unnatural Enantiomer Morphinans as TLR4 Inhibitors

Posted on:2016-05-21Degree:Ph.DType:Thesis
University:University of Colorado at BoulderCandidate:Hartwig, William TFull Text:PDF
GTID:2471390017984592Subject:Analytical Chemistry
Abstract/Summary:
While in the Sammakia Lab, I have focused on developing and applying new approaches to organic synthesis and the creation of novel cell-signaling inhibitors. My research efforts can be classified into (i) the development and application of new methods for the synthesis of novel chemical motifs, and (ii) the use of organic molecules as probes for problems in chemical biology. The use of the Lewis acid, ATNP, which promotes the vinylogous aldol reaction of enolizable aldehydes and ketones with furoate esters, and the design and synthesis of unnatural enantiomer morphinans as inhibitors of Toll-Like Receptor 4 will be discussed.
Keywords/Search Tags:Synthesis
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