| keletal muscle contains cyclic nucleotide-gated cation channels which are responsible for insulin activated sodium uptake into this tissue (J. E. M. McGeoch and G. Guidotti. J. Biol. Chem. 267: 832-841, 1992). In this thesis these channels have been reconstituted, characterized, cloned and expressed in order to better understand this process. These channels can be solubilized from sarcolemma and functionally reconstituted into lipid vesicles as demonstrated by concentrative... |
