Synthesis, conformational analysis and cytotoxic activity of friedelane triterpenoids

Natural friedelane triterpenoid compounds have received attention recently for their pharmacological activities. This thesis describes the preparation of three friedelane triterpenoid derivatives to provide insight into the structure-activity relationship. Their structures have been confirmed by 1H-NMR, 13C-NMR and FTIR spectroscopy. Two compounds exhibit in-vitro cytotoxic activity against Human MDA-MB-231 breast adenocarcinoma and Human 5637 primary bladder carcinoma.; The conformational properties have also been examined using SYBYL, MMFF94 force field molecular mechanics calculations and known X-ray structures.