The effect of medroxyprogesterone (Depo-Provera) on the ovaries of captive cockatiels (Nymphicus holiandicus) during the reproductive cycle

Depo-Provera, a drug manufactured by the Upjohn Company, has been used clinically to prevent egg-laying in several species of domestic birds. Two different doses of the drug plus a placebo injection of saline were administered to 54 cockatiels. All subjects appeared normal and healthy throughout the study except for two birds in the higher dose treatment which died of unknown causes. Control was studied through the direct observation of the ovary by means of laparoscopy, as well as monitoring egg laying activity throughout the study. Depo-Provera at both doses tested appears to effectively decrease egg-laying activity in the captive cockatiel. All birds receiving the higher dose of Depo-Provera gained significant weight. Although the use of Depo-Provera may serve as a means of preventive medicine, there are serious side effects that should be considered.