| Chapter 1. Zr-catalyzed carbomagnesations and kinetic resolutions of cyclic ethers with Grignard reagents are reviewed.*; Chapter 2. Uncatalyzed diastereoselective additions of Grignard reagents to oxepines, which was discovered in the course of investigation of Zr-catalyzed kinetic resolution of oxepines, are detailed. Unlike the Zr-catalyzed process, Grignard reagents other than ethyl readily react with the oxepine system.*; Chapter 3. A tandem Zr-catalyzed kinetic resolution followed by a ring-opening/ring-closing metathesis to give optically pure furans was pursued. The results of these studies are detailed in this chapter.*; Chapter 4. Studies regarding diastereoselective and enantioselective Zr-catalyzed intramolecular alkylations are detailed. Acyclic dienes were cyclized with Cp2ZrCl2 or (ebthi)Zr-binol to give cyclopentane compounds with quaternary carbon centers.*; *Please refer to dissertation for diagrams. |
