Synthesis of carbohydrate-based ligands for the selectins and galectins

The selectin ligands 3;In the search for structurally simple selectin ligand derivatives, mannose- and quinic acid-based derivatives were designed and synthesized as potential L-selectin inhibitors. Preliminary binding data suggests these scaffolds could be useful in the creation of small molecule inhibitors of the selectins.;To generate polyvalent galectin ligands, a norbornene imide derivative possessing a lactose substituent was polymerized by ring-opening metathesis polymerization (ROMP) using the defined ruthenium catalyst ((...