Improvements in PAMAM dendrimer synthesis | Posted on:2002-08-19 | Degree:Ph.D | Type:Thesis | University:University of Cincinnati | Candidate:Dotson, Michael Edward | Full Text:PDF | GTID:2461390011492486 | Subject:Chemistry | Abstract/Summary: | | PAMAM dendrimers have been synthesized using two separate acrylamide monomer compounds, (2-acryloylamino-ethyl)-carbamic acid tert-butyl ester (1) and N-cyanomethyl-acrylamide (18). These monomer units allow for facile synthesis of PAMAM dendrimers with decreased opportunity of defects. Zero and first generations dendrimers have been synthesized with compound 1 and zero through second generation dendrimers have been synthesized with compound 18. Various amine-terminated compounds were used as initiator cores from which the dendrimers were grown. Dendrimers were also grown using 3-[(2-tert-butoxycarbonylamino-ethyl)-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester (9). After selective deprotection of this compound, normal amino acid coupling procedures were used to produce the next higher half-generation dendrimer. | Keywords/Search Tags: | Dendrimers have been synthesized, Acid, Compound, Bold | | Related items |
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