| This study examined the effects of myeloperoxidase (MPO) -463 G to A polymorphism and tobacco smoke on asthma and wheezing in Southern California children while controlling for towns of residence, age, grade, race, gender, family history of asthma and atopy, and gestational age. The results showed that in utero exposure to maternal smoking was statistically significantly associated with all spectrum of wheezing and early onset of asthma of the participants while current ETS did not have any association to the outcomes. There was no association found between MPO genotypes and asthma and wheezing outcomes. The interactions between MPO genotypes and tobacco smoke exposures were not statistically significant. |
