| Chronic exercise training is a common approach utilized to optimize health and prevent disease. While the beneficial physiological adaptations to long term exercise are well established in many systems such as skeletal muscle, the specific alterations that occur in adipose tissue under this condition are less dear. With conflicting results presented in the literature, this study set out to clarify the effects of chronic exercise on adipose tissue lipolysis and lipogenesis in both a visceral and subcutaneous fat depot. Six weeks of exercise training by treadmill running resulted in a significant 26% reduction in isoproterenol stimulated lipolysis in both epididymal and inguinal adipocytes of male Wistar rats. Attempts to elucidate the mechanism underlying this adaptation were unsuccessful but determined that ATGL, CGI-58, perilipin and HSL are likely not responsible. Exercise training also led to a reduction in fat mass that was accompanied by lower triglyceride synthesis. |
