Expression of Immunoglobulin-like Transcript 3 Receptors (ILT-3) by Ovarian Tumors in Laying Hen and its inhibition by dietary supplementation of curcumin

Attempts to enhance a patient's immune response and ameliorate the poor prognosis of ovarian cancer (OVCA) have largely been unsuccessful owing to the suppressive tumor microenvironment. Leukocyte immunoglobulin-like transcript 3 (ILT3) inhibitory receptors have been implicated in immunosuppression in several malignancies. The expression and role of ILT3 in the progression of ovarian tumors are unknown. Our study examined the expression and association of ILT3 in ovarian tumors in laying hens, a spontaneous preclinical model of human OVCA. This study showed that ILT-3 is expressed by ovarian epithelium and its expression increases with ovarian cancer progression. This study also examined the effect of dietary supplementation with curcumin on expression of ILT-3. Our result showed that supplementation with curcumin decreases the expression of ILT-3. In conclusion, ILT-3 can be a target to prevent the progression of ovarian cancer. Dietary supplementation with curcumin may enhance patient immunity by suppression of expression of ILT-3. This study will be a foundation for a clinical study.