| The objective of this study was to determine the impact of a novel prebiotic supplement (Nutrabiotix) on serum lipids in comparison to psyllium fiber. A dietary analysis was also performed in order to observe any potential impact of dietary intake on serum lipids. A total of 42 healthy subjects consumed either 9g or 12g of Nutrabiotix per day for 12 weeks, while the control group consumed 12g psyllium per day for 12 weeks. To increase the ability to detect differences in dietary intake as well as serum lipids, the two Nutrabiotix treatment groups were combined to examine possible differences between the two fiber sources (Nutrabiotix and psyllium). Intakes of all dietary components remained similar to that of the three groups when viewed individually; the changes in dietary intake between time-points did not differ significantly. Changes in serum total cholesterol, LDL-C and non-HDL-C in the psyllium group were as follows: ((median 25th, 75th) (-1.7 (-26.4, 12.5), -6.9 (-31.2, 0.6) and -0.8 (-27.2, 8.4) mg/dL respectively)); however, these differences were not significant (P = 0.75, 0.06 and 0.40 respectively). In the 9g and 12g Nutrabiotix treatment groups non-HDL-C decreased over time; however, these changes were not statistically significant (P = 0.25; 0.65). Overall, no significant differences occurred between the three treatment groups over time, making it unlikely that dietary intake truly impacted any changes in serum lipids, independent of supplementation. The ability of Nutrabiotix to impact serum lipids needs further research with a larger sample size. |
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