| The aim of this project was to develop a new type of respiratory drug delivery carrier particles that incorporate an active release mechanism.;For the effervescent formulation the MMAD was 2.17 mum +/- 0.42, FPF was 46.7% +/- 15 and the GSD was 2.00 +/- 0.06. The effervescent carrier particles can be synthesized with an adequate particle size for lung deposition. This opens the door for future research to explore this technology for delivery of a large range of substances to the lungs with possible improved release compared to conventional carrier particles.;Spray drying was used to manufacture powders containing polybutylcyanoacrylate nanoparticles and ciprofloxacin as model substances for pulmonary delivery. The carrier particles incorporated effervescent technology, thereby adding an active release mechanism to their pulmonary route of administration. Effervescent activity of the carrier particles was observed when the carrier particles were exposed to humidity. |
