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Comparative phyto-uptake across distribution coefficients of pharmaceutical compounds and aquatic macrophytes: Carbamazepine and amiodarone uptake in Lemna spp.

Posted on:2014-04-28Degree:M.SType:Thesis
University:University of North TexasCandidate:Woodard, Jennifer KristinFull Text:PDF
GTID:2453390008461305Subject:Environmental Science
Abstract/Summary:
Few studies have been conducted on the effectiveness of phytoremediation of pharmaceutical compounds, although the persistent and non-acutely toxic nature of many of these compounds in today's water bodies may yield an ideal application for this practice. To quantify the potential effectiveness of plant uptake, kinetic and proportional bioconcentration factors (BCF k, and BCFp, respectively) in nanograms (ng) carbamazepine and amiodarone per gram (g) wet weight plant tissue for Lemna spp. were determined utilizing a 14-day continuous flow-through study. Samples were analyzed using isotope dilution liquid chromatography-tandem mass spectrometry (IDLC-MS/MS) running in positive ion mode.;Kinetic BCF was estimated at 0.538, while proportional BCF was estimated at 0.485. Kinetic BCF for the amiodarone study was estimated at 23.033, whereas proportional BCF was estimated at 41.340. Possible contamination of the C 18 column and peristaltic pump failure may have impacted uptake results. In light of variability and current lack of research in the field, this work should be considered exploratory rather than conclusive.
Keywords/Search Tags:BCF was estimated, Compounds, Amiodarone, Uptake
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