Coordination chemistry of rhenium(I) carbonyl complexes as pharmaceutically important compounds and synthesis, characterization, and metalation of novel phthalocyanine analogs

The significant expansion of the synthesis of technetium and rhenium compounds has resulted from the interest in their diagnostic and therapeutic nuclear medicinal applications. One main goal for future Tc/Re radiopharmaceuticals is to find robust compounds that can withstand harsh biological conditions. Recent work has shown that compounds based on the [Re/Tc(CO)3] + core exhibit increased resistance towards decomposition. The radionuclide 99mTc is a gamma-emitter with a medically useful energy and half-life which is appropriate for the requirements of preparing and administrating diagnostic imaging agents. The chemistry of rhenium is very similar to that of technetium, and it can be used to model technetium complexes. The first part of this dissertation describes the preparation, characterization and properties of Re(CO)3+ complexes for possible medicinal applications using oxime, dithiocarbamate, and pyridylimine-based ligand systems.;One important class of phthalocyanine analogs is known as the hemiporphyrazines and was first synthesized by Elvidge and Linstead more than five decades ago. In some of these macrocycles, nitrogen atoms in the core are replaced by one or more carbon atoms, similar to carbaporphyrins. This type of phthalocyanine analog can be obtained by replacing one or two diiminoisoindoline units with other heterocycle rings. A phthalocyanine with a single isoindoline replaced with one benzene ring is known as benziphthalocyanine and a phthalocyanine with two opposite isoindoline rings replaced with benzene rings is known as dicarbahemiporhyrazine. The second part of the dissertation describes the preparation, characterization of similarly structured hemiporphyrazines, by incorporating phenol, resorcinol and cyclohexane, and metalation chemistry by preparing Ag(I) and Co(II) metal adducts.