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Modulation of morpho-functional characteristics of astrocytes using chemically-functionalized water-soluble single-walled carbon nanotubes

Posted on:2013-10-18Degree:M.S.B.M.EType:Thesis
University:The University of Alabama at BirminghamCandidate:Gottipati, Manoj KFull Text:PDF
GTID:2451390008477355Subject:Engineering
Abstract/Summary:
In this thesis, I report the use of chemically functionalized water-soluble single-walled carbon nanotubes (ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When added to the culturing medium, ws-SWCNTs were able to make astrocytes larger and stellate/mature, changes associated with the increase in glial fibrillary acidic protein immunoreactivity. Thus, ws-SWCNTs could have more beneficial effects at the injury site than previously thought; by affecting astrocytes, they could provide for a more comprehensive re-establishment of the brain computational power.;Keywords: Carbon nanotubes, graft copolymers, astrocytes, glial fibrillary acidic protein.
Keywords/Search Tags:Carbon, Astrocytes
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