| Natural product synthesis is a complex array of different methodologies used to construct a single molecule. Described herein is a detailed approach towards two different classes of natural products. Chapters one and two focus on the synthesis of 6,6'-binaphthopyran-2-one natural products utilizing a key vanadium-catalyzed oxidative biaryl coupling to access these axial chiral molecules. Chapter three focuses on the synthetic progress towards a class of macrocyclic and linear E-chloroalkene natural products. The latter, although unfinished, has provided crucial insight into the synthetic feasibility of these natural products. |
