Font Size: a A A

New methods for medium ring synthesis: Towards the total synthesis of clavirolide B

Posted on:2007-08-31Degree:Ph.DType:Thesis
University:Boston CollegeCandidate:White, Brian HFull Text:PDF
GTID:2451390005486138Subject:Chemistry
Abstract/Summary:
Chapter 1. Review of the use of cyclobutenes in the total synthesis of natural products.; Chapter 2. Presentation of a methodology for the synthesis of bicyclic medium ring systems by ring-closing/ring-opening olefin metathesis followed by oxy-Cope rearrangement.*; Chapter 3. Efforts toward the total synthesis of the dolabellane diterpene clavirolide B utilizing an intermolecular Lewis-acid catalyzed cycloaddition, an intermolecular [2+2] photocycloaddition, and thermal fragmentation of the resulting photoadduct.*; *Please refer to dissertation for diagrams.
Keywords/Search Tags:Total synthesis
Related items
1 New methods and strategies for heterocycle synthesis: Progress toward the total synthesis of upenamide and the total synthesis of (+)-5-epiindolizidine 167B and indolizidine 223AB
2 Total synthesis of ht-13-A and ht-13-B, total synthesis of aurantioclavine, progress towards the synthesis of cycloclavine
3 Enantiospecific stereospecific total synthesis of the oxindole alkaloid (+)-alstonisine and stereocontrolled total synthesis of (-)-11-methoxy-17-epivincamajine as well as studies directed toward the total synthesis of N(b)-demethylalstophylline oxindole
4 Part I: The first regio- and atropdiastereoselective total synthesis of the dimeric indole alkaloid (+)-dispegatrine, as well as the first total synthesis of the sarpagine alkaloids (+)-spegatrine, lochvinerine, (+)-lochneram and an improved total synthes
5 Total Syntheses Of (+)-Agelastatin A And B, Longifolene And (+)-Minfiensine, And Studies Toward Total Synthesis Of Daphniyunnine C
6 One-Pot Total Synthesis Of Natural Products And New Synthetic Methodology Of Relative N-Containing Heterocycles From Amino Acids
7 I. Total synthesis of trichoaurantianolide C and D II. Studies toward the total synthesis of norzoanthamine
8 Asymmetric Total Synthesis of Cylindrocyclophanes A and F through Cyclodimerization and a Ramberg--Backlund Reaction and Studies Directed Towards the Total Synthesis of CJ-16,264
9 The total synthesis of biologically active C-glycoside natural products: 1) Total synthesis of (-)-centrolobine 2) Total synthesis of (-)-varitriol and analogues 3) Progress towards the total synthesis of polyrhacatide A
10 The First Total Synthesis Of(±)-δ-Rubromycin,(+)-Coriandrone A And B&Studies On The Total Synthesis Of Vigatolide B