| A signal peptide is a short stretch of amino acids found at the beginning of proteins. It is typically rich in hydrophobic amino acids. One of the major functionalities of the signal peptide is to localize proteins to specific regions within the cell. Therefore, knowledge of a specific signal peptide for a protein provides an important clue to its likely locations. In this thesis, we propose a new method to detect the presence of the signal peptide based on the space-frequency processing of the numeric amino acid sequences.; There are more than 400 index mappings available which map the symbolic amino acid sequences to numeric representations. Therefore, the selection of the index mapping becomes an important issue. In this thesis, we propose a method to select the index mappings which is suitable for signal peptide detection. To detect the presence of the signal peptide in an amino acid sequence, the numeric sequence is transformed to the space-frequency domain by the Wigner-Ville transform. We observed that the amino acid sequence with signal peptide tends to have smaller variance in the space-frequency domain than the amino acid sequence without signal peptide. Based on this observation, we devised a new signal peptide detection algorithm which effectively differentiates between the amino acid sequences with the signal peptide and the amino acid sequence without the signal peptide. (Abstract shortened by UMI.)... |
