A non-rigid registration method for analyzing myocardial wall motion for cardiac CT images

Cardiac resynchronization therapy (CRT) has a high percentage of non-responders. Successfully locating the optimal location for CRT lead placement on a priori images can increase efficiency in procedural preparation and execution and could potentially increase the rate of CRT responders.;Registration has been used in the past to assess the motion of medical images. Specifically, one method of non-rigid registration has been utilized to assess the motion of left ventricular MR cardiac images. As CT imaging is often performed as part of resynchronization treatment planning and is a fast and accessible means of imaging, extending this registration method to assessing left ventricular motion of CT images could provide another means of reproducible contractility assessment.;This thesis investigates the use of non-rigid registration to evaluate the myocardium motion in multi-phase multi-slice computed tomography (MSCT) cardiac imaging for the evaluation of mechanical contraction of the left ventricle.