| The effect of several adenosine receptor antagonists were assessed on an animal model of Parkinson's disease (PD) to examine if the compounds had any effect in facilitating movement of a Sprague-Dawley rat. Gross motor movement was measured in an open-field design to assess the total distance that the animal traveled. A chemical model of PD was obtained using haloperidol (i.p.) 50 minutes before observations, and the adenosinergic compounds used were caffeine, KF17837, SCH58261, and CPT. The results were perplexing; as expected, caffeine significantly restored movement, but in contrast with expected results, the A1 antagonist exhibited a restoration of gross motor movement abilities in the animal that was given CPT. In addition, the adenosinergic A2A antagonists (SCH58261 and KF17837) did not produce a significant restoration in movement; these findings contradicted our hypotheses. |
