| Extraction of mandibular premolars 2, 3 and 4 were performed bilaterally in seven Foxhounds. After 8 weeks, standardized osseous ridge defects were created using a 6 mm trephine. A total of 20 defects were created and allocated to two groups: autogenous bone covered by a human pericardium membrane (PHP) and non-augmented control sites (Ctrl). All seven animals were sacrificed 12 weeks after the augmentation procedures. Twenty sites were available for evaluation. No soft tissue dehiscences were detected following augmentation in any group. Comparison of findings using paired t-test revealed statistically significant differences in mean total area (PHP=22.88 mm2 and Ctrl=20.17 mm2), percentage of bone (PHP=53.79% and Ctrl=38.76%) and width of regenerated bone (PHP=2.46 mm and Ctrl=2.08 mm at the coronal third and PHP=3.16 mm and Ctrl=2.74 mm at the middle third). The results of this study indicated that osseous regeneration of an alveolar ridge defect was greater for sites treated using autogenous bone graft with a barrier of human pericardium membrane. |
