Dynamic interleaved imaging of pyruvate metabolism with hyperpolarized carbon-13 |
Posted on:2011-07-01 | Degree:M.Sc | Type:Thesis |
University:University of Toronto (Canada) | Candidate:Leung, Kevin Kai-Chi | Full Text:PDF |
GTID:2444390002969950 | Subject:Health Sciences |
Abstract/Summary: | |
Dynamic nuclear polarization and dissolution of 13C-labeled metabolite allows dynamic imaging of metabolism in-vivo. However, the spatial and temporal resolutions of magnetic resonance spectroscopic imaging are limited by the duration of free-induction decay acquisitions and the T 1-based, non-recoverable polarization decay. This thesis describes the implementation of a spectral-spatial radiofrequency excitation pulse with a 'flyback' echo-planar readout trajectory to dynamically image [1-13C]-pyruvate and [1-13C]-lactate in an interleaved manner. This technique excites a single resonance of either [1-13C]-pyruvate or [1-13C]-lactate and generates dynamic images with 5mm in-plane resolution. Metabolite dynamics extracted from the images and the corresponding non-localized spectroscopic data reveal similar kinetic rates upon fitting to a kinetic model. This demonstrates the feasibility of probing metabolism in heterogeneous tissues in-vivo with dynamic interleaved 13C MR imaging. |
Keywords/Search Tags: | Dynamic, Imaging, Metabolism, Interleaved |
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